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Illustrations of recent publications

Autoproteolytic  fragments are intermediates in the oligomerization/aggregation of the  Parkinson's disease protein alpha-synuclein as revealed by ion mobility  mass spectrometry.

(Vlad C et al., ChemBioChem 2011 12(18) 2740-2744)

Toward Bioinspired Galectin Mimetics: Identification of Ligand-Contacting Peptides by Proteolytic-Excision Mass Spectrometry.

(Moise A et al., 2011 J. Am. Chem. Soc. 133(38) 14844-14847)

Structural characterization of beta-amyloid oligomer-aggregates by  ion mobility mass spectrometry and electron spin resonance spectroscopy.  

(Iurascu MI et al., Anal. Bioanal. Chem. 2010 395, 2509-2519)

Functional ubiquitin conjugates with lysine-epsilon-amino-specific linkage  by thioether ligation of cysteinyl-ubiquitin peptide building blocks.                       

(Jung JE et al., Bioconj. Chem. 2009 20 1152-1162)

"Unknown genome" proteomics: a new NADP-dependent epimerase/dehydratase revealed by  N-terminal sequencing, inverted PCR, and high resolution mass spectrometry.    

(Simeonova DD, Susnea I et al., Mol Cell Proteomics 2009 8(1), 122-131)

Elucidation of O-Glycosylation Structures of the Aß-Amyloid Precursor Protein by Liquid Chromatography-Mass Spectrometry Using Electron Transfer Dissociation and Collision Induced Dissociation

(Perdivara I. et al., J. Proteome Res 8 (2) 631-642)

Binding Epitopes and Interaction Structure of the Neuroprotective Protease Inhibitor Cystatin C with ß-Amyloid Revealed by Proteolytic Excision Mass Spectrometry and Molecular Docking Simulation

(Juszczyk P. et al., J. Med. Chem. 2009 52, 2420–2428)

"Peptidbody" Design: Functional single-chain peptide anti-lysozyme antibody, revealed by high-resolution affinity - mass spectrometry                    
(A. Marquardt et al., Chemistry 2006 12(7): 1915-1923)

Proteolytic specificity of serine protease HtrA1 & implications for amyloid precursor protein (APP) processing revealed by FTICR-MS

(S. Grau et al., Proc Natl Acad Sci USA 2005, 102(17), 6021)

Elucidation of a plaque-specific epitope β-amyloid (4-10) provides Alzheimer-vaccine lead structure

(J. McLaurin et al., Nature Med 2002, 8, 1263; M. Manea et al., Biopolymers 2004, 76, 503)
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